Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4877752 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
48777524878558807hypothetical proteinBLASTP
48787214879686966thioredoxin reductaseQuickGO ontologyBLASTP
487976248812731512TPR domain proteinQuickGO ontologyBLASTP
48814134881925513bacterial transferase hexapeptide domain proteinQuickGO ontologyBLASTP
48819494882599651hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
48826674883479813prolipoprotein diacylglyceryl transferaseQuickGO ontologyBLASTP
48835044884433930HPr kinasephosphorylaseQuickGO ontologyBLASTP
48845904884970381hypothetical proteinBLASTP
48850854885534450hypothetical proteinBLASTP
488559448884702877excinuclease ABC subunit AQuickGO ontologyBLASTP
488847648904521977excinuclease ABC subunit BQuickGO ontologyBLASTP
489061348917701158transposase IS605 familyQuickGO ontologyBLASTP
48921884892619432lipoprotein putativeQuickGO ontologyBLASTP
48926654893285621hypothetical proteinBLASTP
48932824894046765transcriptional regulator MerR familyQuickGO ontologyBLASTP
48943874894779393hypothetical proteinBLASTP
48947764894997222hypothetical proteinBLASTP
48950104895207198DNA-binding proteinQuickGO ontologyBLASTP
489554248966001059hypothetical proteinBLASTP