Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4854951 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485366948549791311hypothetical proteinBLASTP
48549514855448498prophage LambdaBa03 prohead protease putativeQuickGO ontologyBLASTP
485546948565481080phage major capsid protein HK97 familyQuickGO ontologyBLASTP
48566354857615981hypothetical proteinBLASTP
48576834858549867hypothetical proteinBLASTP
48586724859577906prophage LambdaBa03 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
485972148610161296enolaseQuickGO ontologyBLASTP
486104748625761530phosphoglyceromutaseQuickGO ontologyBLASTP
48625734863328756triosephosphate isomeraseQuickGO ontologyBLASTP
486336148645451185phosphoglycerate kinaseQuickGO ontologyBLASTP
486468548656891005glyceraldehyde-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
486571648667441029gapA transcriptional regulator CggRQuickGO ontologyBLASTP
48668814867126246glutaredoxin family proteinQuickGO ontologyBLASTP
486713648684431308DNA-directed RNA polymerase subunit NQuickGO ontologyBLASTP
4868696486877782tRNA-ArgQuickGO ontologyBLASTP
48689834869189207hypothetical proteinBLASTP
48692264869768543lipoprotein putativeQuickGO ontologyBLASTP
48697994870275477stage V sporulation protein ACQuickGO ontologyBLASTP
487027648712921017stage V sporulation protein SpoVADQuickGO ontologyBLASTP
48712894871639351stage V sporulation protein AEQuickGO ontologyBLASTP
48716514871857207hypothetical proteinBLASTP
48718784872747870hypothetical proteinBLASTP
48729894873570582ATP-dependent Clp protease proteolytic subunitQuickGO ontologyBLASTP
48738944874142249phosphocarrier protein HPrQuickGO ontologyBLASTP