Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4747740 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
474774047487531014hypothetical proteinBLASTP
47487764749726951L-lactate dehydrogenaseQuickGO ontologyBLASTP
47499724750220249spore coat protein F-related proteinQuickGO ontologyBLASTP
47502344750419186hypothetical proteinBLASTP
47505664751279714CAAX amino terminal protease family proteinQuickGO ontologyBLASTP
47518674752415549transcriptional regulator putativeQuickGO ontologyBLASTP
47524194753141723metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
475328047550641785acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
475533947565111173acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
4756533475891423823-hydroxyacyl-CoA dehydrogenaseenoyl-CoA hydrataseisomerase family proteinQuickGO ontologyBLASTP
47593844760223840D-alanyl-D-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
47602464761163918proline dehydrogenase family proteinQuickGO ontologyBLASTP
47614734761718246hypothetical proteinBLASTP
47617674762069303conserved hypothetical protein TIGR00106QuickGO ontologyBLASTP
476214747641472001methyl-accepting chemotaxis proteinQuickGO ontologyBLASTP
47643364765094759hypothetical proteinBLASTP
476512547670081884cell wall surface anchor family proteinQuickGO ontologyBLASTP