Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:467427 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
466481467479999conserved hypothetical protein phage-likeQuickGO ontologyBLASTP
467427468017591prophage LambdaBa04 prohead protease putativeQuickGO ontologyBLASTP
4680244692261203prophage LambdaBa04 major capsid protein putativeQuickGO ontologyBLASTP
469242469499258hypothetical proteinBLASTP
469496469768273prophage LambdaBa04 DNA packaging protein putativeQuickGO ontologyBLASTP
469765470064300hypothetical proteinBLASTP
470057470413357hypothetical proteinBLASTP
470410470739330hypothetical proteinBLASTP
470740471309570prophage LambdaBa04 major tail protein putativeQuickGO ontologyBLASTP
471314471676363hypothetical proteinBLASTP
4719184758533936prophage LambdaBa04 tape measure protein putativeQuickGO ontologyBLASTP
475850476659810hypothetical proteinBLASTP
4766744802523579hypothetical proteinBLASTP
4805484821821635phage minor structural proteinQuickGO ontologyBLASTP
482200482679480hypothetical proteinBLASTP
482774483013240hypothetical proteinBLASTP
483229484026798prophage LambdaBa04 glycosyl hydrolase family 25 putativeQuickGO ontologyBLASTP
484080484415336hypothetical proteinBLASTP
484795485532738tRNA pseudouridine synthase AQuickGO ontologyBLASTP
485583485786204hypothetical proteinBLASTP
4858704872731404arginine utilization regulatory protein RocRQuickGO ontologyBLASTP
487547487801255acetyl-CoA carboxylaseQuickGO ontologyBLASTP
4879064893271422amino acid permease family proteinQuickGO ontologyBLASTP
4894234907031281acetylornithine deacetylaseQuickGO ontologyBLASTP