Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4670978 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
467097846723121335arsenical pump family proteinQuickGO ontologyBLASTP
46723714672838468hypothetical proteinBLASTP
46729574673670714hypothetical proteinBLASTP
467401846753941377glycyl-tRNA synthetaseQuickGO ontologyBLASTP
46754324675815384comA operon protein putativeQuickGO ontologyBLASTP
46759114676654744hypothetical proteinBLASTP
46767054677298594bioY family proteinQuickGO ontologyBLASTP
46774464678282837hypothetical proteinBLASTP
46783884679275888UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
467938446811081725phosphoglucomutasephosphomannomutase family proteinQuickGO ontologyBLASTP
46812524681857606hypothetical proteinBLASTP
468194046834241485leucyl aminopeptidaseQuickGO ontologyBLASTP
46835714684230660hypothetical proteinBLASTP
46842844684601318hypothetical proteinBLASTP
46845984685104507mutTnudix family proteinQuickGO ontologyBLASTP
468522846864391212pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
46868934687888996pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
468800746940846078cell surface protein gram positive anchorQuickGO ontologyBLASTP