Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4508304 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45083044508627324transcriptional regulator ArsR familyQuickGO ontologyBLASTP
45086284509059432hypothetical proteinBLASTP
45094324509710279hypothetical proteinBLASTP
45097454509927183hypothetical proteinBLASTP
45099294510165237hypothetical proteinBLASTP
45104214510882462transcriptional regulator CarD familyQuickGO ontologyBLASTP
45109424511727786glucose-1-dehydrogenaseQuickGO ontologyBLASTP
45117414512598858glucose uptake proteinQuickGO ontologyBLASTP
45126354513054420hypothetical proteinBLASTP
45131484513381234molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
45133844513848465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
45138454514360516molybdopterin-guanine dinucleotide biosynthesis protein MobBQuickGO ontologyBLASTP
451433045156191290molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
45157034516188486molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
451622745172401014molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
45172574517505249molybdenum cofactor biosynthesis protein A C-terminusQuickGO ontologyBLASTP
45175514518309759molybdenum cofactor biosynthesis protein A N-terminusQuickGO ontologyBLASTP
451844645203891944collagen triple helix repeat domain proteinQuickGO ontologyBLASTP
45205514520874324hypothetical proteinBLASTP
45208954521119225hypothetical proteinBLASTP
45211974521502306rhodanese-like domain proteinQuickGO ontologyBLASTP
45217034521885183hypothetical proteinBLASTP
452193545230591125homoserine O-acetyltransferaseQuickGO ontologyBLASTP
452321245254552244spore germination protein GerHAQuickGO ontologyBLASTP
452547345265671095spore germination protein GerHBQuickGO ontologyBLASTP
452654345276221080spore germination protein GerHCQuickGO ontologyBLASTP
45277014527898198hypothetical proteinBLASTP
45280884528510423hypothetical proteinBLASTP
45285554529316762vrrB proteinQuickGO ontologyBLASTP
452957345319812409leucyl-tRNA synthetaseQuickGO ontologyBLASTP