Pre_GI Gene

Some Help

Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4473790 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44737904474188399large conductance mechanosensitive channel proteinQuickGO ontologyBLASTP
44742394474511273hypothetical proteinBLASTP
44746474474958312minD family ATPase domain proteinQuickGO ontologyBLASTP
44750404475276237hypothetical proteinBLASTP
44752664475640375hypothetical proteinBLASTP
44756754476673999catabolite control protein AQuickGO ontologyBLASTP
447720244782181017lipoprotein putativeQuickGO ontologyBLASTP
44783364478665330hypothetical proteinBLASTP
44786624479174513hypothetical proteinBLASTP
447936244804771116aminopeptidase putativeQuickGO ontologyBLASTP
44805144480948435lipoprotein putativeQuickGO ontologyBLASTP
44811434481547405hypothetical proteinBLASTP
44816394482193555ribosomal-protein-serine acetyltransferase putativeQuickGO ontologyBLASTP
448239044837001311UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
448395344850711119nicotinate phosphoribosyltransferaseQuickGO ontologyBLASTP
448513344890683936FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
44892904489634345hypothetical proteinBLASTP
44900694490683615tRNA binding domain protein putativeQuickGO ontologyBLASTP
44906804491492813hypothetical proteinBLASTP
44915724491886315thioredoxin family proteinQuickGO ontologyBLASTP
44919704492479510hypothetical proteinBLASTP
449272144937941074peptidase M42 familyQuickGO ontologyBLASTP