Pre_GI Gene

Some Help

Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4399756 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43997564400694939malate dehydrogenaseQuickGO ontologyBLASTP
440071444020211308isocitrate dehydrogenaseQuickGO ontologyBLASTP
440216744032821116citrate synthaseQuickGO ontologyBLASTP
44037034404164462hypothetical proteinBLASTP
440458544057031119hypothetical proteinBLASTP
44062894406678390fxsA cytoplasmic membrane protein putativeQuickGO ontologyBLASTP
440687844086351758pyruvate kinaseQuickGO ontologyBLASTP
440868944096489606-phosphofructokinaseQuickGO ontologyBLASTP
44097774410751975acetyl-CoA carboxylase alpha subunitQuickGO ontologyBLASTP
44107394411608870acetyl-CoA carboxylase beta subunitQuickGO ontologyBLASTP
44117944412438645transcriptional regulator GntR familyQuickGO ontologyBLASTP
441245344136911239malate dehydrogenase putativeQuickGO ontologyBLASTP
441379544171213327DNA polymerase III subunit alphaQuickGO ontologyBLASTP
44172394417577339hypothetical proteinBLASTP
44175744418077504hypothetical proteinBLASTP
44181294419061933DHH subfamily 1 proteinQuickGO ontologyBLASTP