Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:4116978 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41166284116981354diacylglycerol kinaseQuickGO ontologyBLASTP
41169784117448471hypothetical proteinBLASTP
411744541195892145HDIG domain proteinQuickGO ontologyBLASTP
41197834120742960PhoH family proteinQuickGO ontologyBLASTP
412074641219451200sporulation proteinQuickGO ontologyBLASTP
41221224122415294hypothetical proteinBLASTP
41225244122967444gatBYqey domain proteinQuickGO ontologyBLASTP
4122983412315617430S ribosomal protein S21QuickGO ontologyBLASTP
412348741248391353hypothetical proteinBLASTP
41248464125595750conserved hypothetical protein TIGR00046QuickGO ontologyBLASTP
41257414126679939ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
412670841278231116chaperone protein dnaJQuickGO ontologyBLASTP
412802841298631836molecular chaperone DnaKQuickGO ontologyBLASTP
41298904130456567GrpE proteinQuickGO ontologyBLASTP
413057141315871017heat-inducible transcription repressorQuickGO ontologyBLASTP
413172141328601140coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
41329134133287375hypothetical proteinBLASTP
413341941352421824GTP-binding protein LepAQuickGO ontologyBLASTP