Pre_GI Gene

Some Help

Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3747652 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37470873747710624hypothetical proteinBLASTP
374765237488331182prophage LambdaBa02 FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
37489493749131183hypothetical proteinBLASTP
37491343749436303hypothetical proteinBLASTP
37496203749826207prophage LambdaBa02 repressor proteinQuickGO ontologyBLASTP
37498303750012183hypothetical proteinBLASTP
37500183750599582hypothetical proteinBLASTP
37506633751367705prophage LambdaBa02 N-acetylmuramoyl-L-alanine amidase family 2QuickGO ontologyBLASTP
37513673751792426prophage LambdaBa02 holin putativeQuickGO ontologyBLASTP
37517973752774978prophage LambdaBa02 site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
37529213753196276prophage LambdaBa02 transcriptional regulator AbrB familyQuickGO ontologyBLASTP
375322137553352115hypothetical proteinBLASTP
375532337573051983phage minor structural proteinQuickGO ontologyBLASTP
375730237587861485hypothetical proteinBLASTP
37588203759431612hypothetical proteinBLASTP
375949737608851389hypothetical proteinBLASTP
376095437638332880prophage LambdaBa02 tape measure protein putativeQuickGO ontologyBLASTP
37638493764085237hypothetical proteinBLASTP
37639913764437447hypothetical proteinBLASTP
37644613765045585prophage LambdaBa02 major tail protein putativeQuickGO ontologyBLASTP
37650593765418360hypothetical proteinBLASTP
37654153765852438hypothetical proteinBLASTP
37658403766196357hypothetical proteinBLASTP
37661743766449276hypothetical proteinBLASTP