Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3693471 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
369347136951801710fibronectinfibrinogen-binding protein putativeQuickGO ontologyBLASTP
369550836965781071proline dipeptidase putativeQuickGO ontologyBLASTP
36966983697066369hypothetical proteinBLASTP
36970823697447366hypothetical proteinBLASTP
369761436989991386hypothetical proteinBLASTP
36991663699420255hypothetical proteinBLASTP
36994433699754312hypothetical proteinBLASTP
37001623700794633orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37007913701507717orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
37014923702421930dihydroorotate dehydrogenaseQuickGO ontologyBLASTP
37024183703197780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
370319437064123219carbamoyl-phosphate synthase large subunitQuickGO ontologyBLASTP
370639737074941098carbamoyl-phosphate synthase small subunitQuickGO ontologyBLASTP
370749137087771287dihydroorotaseQuickGO ontologyBLASTP
37087613709675915aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
370982437111401317uracil permeaseQuickGO ontologyBLASTP
37112543711796543pyrimidine regulatory protein PyrRQuickGO ontologyBLASTP
37119993712907909RNA pseudouridylate synthaseQuickGO ontologyBLASTP