Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3615623 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36156233616222600hypothetical proteinBLASTP
36162193617121903dipicolinate synthaseQuickGO ontologyBLASTP
36173963617647252hypothetical proteinBLASTP
361777436190151242zinc protease insulinase familyQuickGO ontologyBLASTP
36191023620001900polysaccharide deacetylase putativeQuickGO ontologyBLASTP
362015336222912139polyribonucleotide nucleotidyltransferaseQuickGO ontologyBLASTP
3622452362272127030S ribosomal protein S15QuickGO ontologyBLASTP
36228223623793972hypothetical proteinBLASTP
36238373624760924tRNA pseudouridine synthase BQuickGO ontologyBLASTP
36248473625203357ribosome-binding factor AQuickGO ontologyBLASTP
36252193625500282hypothetical proteinBLASTP
362549736275572061translation initiation factor IF-2QuickGO ontologyBLASTP
36275623627873312hypothetical proteinBLASTP
36278743628155282hypothetical proteinBLASTP
362815836292641107transcription elongation factor NusAQuickGO ontologyBLASTP
36292823629752471hypothetical proteinBLASTP
363008536343864302DNA polymerase III subunit alphaQuickGO ontologyBLASTP