Pre_GI Gene

Some Help

Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3581776 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
358177635833051530hypothetical proteinBLASTP
35837333584599867ferrodoxin oxidoreductase beta subunitQuickGO ontologyBLASTP
358458635863431758pyruvate ferredoxin oxidoreductase alpha subunit putativeQuickGO ontologyBLASTP
35865713587494924renal dipeptidase family proteinQuickGO ontologyBLASTP
35875543587814261stage V sporulation protein SQuickGO ontologyBLASTP
35879643588758795phosphoesterase family proteinQuickGO ontologyBLASTP
358892435904861563hypothetical proteinBLASTP
359247235937101239competence damage-inducible protein AQuickGO ontologyBLASTP
35937313594309579CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
35943733595284912hypothetical proteinBLASTP
35953063596091786ACT domain proteinQuickGO ontologyBLASTP
35962313596479249hypothetical proteinBLASTP
359655535972687143-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
359737235986581287zinc protease insulinase familyQuickGO ontologyBLASTP
359865935999331275hypothetical proteinBLASTP