Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3463199 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346319934652052007hypothetical proteinBLASTP
346528134679322652prophage LambdaBa01 minor structural proteinQuickGO ontologyBLASTP
34679293468837909phage-related protein C-terminusQuickGO ontologyBLASTP
34689003469409510phage-related protein N-terminusQuickGO ontologyBLASTP
346945134718862436prophage LambdaBa01 membrane protein putativeQuickGO ontologyBLASTP
347210134733511251hypothetical proteinBLASTP
34735693473940372hypothetical proteinBLASTP
34739453474538594prophage LambdaBa01 major tail protein putativeQuickGO ontologyBLASTP
34745393474868330hypothetical proteinBLASTP
34748653475221357hypothetical proteinBLASTP
34752143475513300hypothetical proteinBLASTP
34755103475782273hypothetical proteinBLASTP
34757853476075291hypothetical proteinBLASTP
347611234772751164phage major capsid protein putativeQuickGO ontologyBLASTP
34772893477873585prophage LambdaBa01 prohead protease putativeQuickGO ontologyBLASTP
347783934790501212hypothetical proteinBLASTP
347906634807541689prophage LambdaBa01 terminase large subunit putativeQuickGO ontologyBLASTP
34807513481122372hypothetical proteinBLASTP
34812883481584297conserved hypothetical protein possible phage-related proteinQuickGO ontologyBLASTP
34823493482771423hypothetical proteinBLASTP
34828583483283426hypothetical proteinBLASTP
34834043483682279hypothetical proteinBLASTP
34842513485078828hypothetical proteinBLASTP
34851423486125984hypothetical proteinBLASTP