Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3415135 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
341513534166521518histidine ammonia-lyaseQuickGO ontologyBLASTP
34167573417197441anti-terminator HutPQuickGO ontologyBLASTP
34173703418338969hypothetical proteinBLASTP
34183523418924573thiJpfpI family proteinQuickGO ontologyBLASTP
34189213419451531hypothetical proteinBLASTP
34197063420002297hypothetical proteinBLASTP
34201063420546441hypothetical proteinBLASTP
342057634216551080hypothetical proteinBLASTP
34219233422150228conserved repeat domain proteinQuickGO ontologyBLASTP
34222123422529318hypothetical proteinBLASTP
342314334294846342conserved repeat domain proteinQuickGO ontologyBLASTP
34295473430053507ccdC proteinQuickGO ontologyBLASTP
34301443430851708cytochrome c-type biogenesis protein CcdAQuickGO ontologyBLASTP
34310553431630576hypothetical proteinBLASTP
34318613432766906als operon regulatory protein AlsR putativeQuickGO ontologyBLASTP
34329193433284366holin-like proteinQuickGO ontologyBLASTP
34332813433958678hypothetical proteinBLASTP
34339713434384414mutTnudix family proteinQuickGO ontologyBLASTP
34345263434726201hypothetical proteinBLASTP
34351643435799636hypothetical proteinBLASTP
343621934379461728N-acetylmuramoyl-L-alanine amidase family 2QuickGO ontologyBLASTP
34381623438728567hypothetical proteinBLASTP
343873534397541020hypothetical proteinBLASTP
343987334416361764ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
344163634433871752ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP