Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3321600 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
332160033234531854squalene-hopene cyclaseQuickGO ontologyBLASTP
33235533323978426hypothetical proteinBLASTP
33240583324999942rarD proteinQuickGO ontologyBLASTP
33250903325338249hypothetical proteinBLASTP
33255073325905399hypothetical proteinBLASTP
33259483326172225hypothetical proteinBLASTP
332618833272371050mrp proteinQuickGO ontologyBLASTP
33273043327570267molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
33275453328009465molybdopterin converting factor subunit 2QuickGO ontologyBLASTP
332799033292971308molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
332931633303321017molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
33303573331136780formate transporter putativeQuickGO ontologyBLASTP
333132633323421017molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
33323633333160798formate dehydrogenase accessory proteinQuickGO ontologyBLASTP
33331773333521345hypothetical proteinBLASTP
33336373334119483hypothetical proteinBLASTP
333413133370702940molybdopterin oxidoreductase family proteinQuickGO ontologyBLASTP
33370393337230192hypothetical proteinBLASTP
333736833389061539spore germination proteinQuickGO ontologyBLASTP
333890333400001098spore germination proteinQuickGO ontologyBLASTP
334000133411371137spore germination proteinQuickGO ontologyBLASTP
334140933447713363hypothetical proteinBLASTP