Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:2716000 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27160862716934849hypothetical proteinBLASTP
27172202717717498hypothetical proteinBLASTP
271791227203442433hypothetical proteinBLASTP
27205892721155567transcriptional regulator TetR familyQuickGO ontologyBLASTP
272142527225971173acetyltransferase GNAT familyQuickGO ontologyBLASTP
2722768272405712903-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
272407427251741101prephenate dehydrogenaseQuickGO ontologyBLASTP
272516727262671101putative aminotransferaseQuickGO ontologyBLASTP
272628627274581173chorismate synthaseQuickGO ontologyBLASTP
2727743272881910773-deoxy-7-phosphoheptulonate synthaseQuickGO ontologyBLASTP
272965127322002550hypothetical proteinBLASTP
27322442733161918hypothetical proteinBLASTP
27333112733748438hypothetical proteinBLASTP
27338972734427531isochorismatase family proteinQuickGO ontologyBLASTP
27344442734977534acetyltransferase GNAT familyQuickGO ontologyBLASTP
27349972735296300hypothetical proteinBLASTP
27353982735913516hypothetical proteinBLASTP
273596527372871323hypothetical proteinBLASTP
27376252738623999hypothetical proteinBLASTP
27386132739191579RNA polymerase sigma-70 factorQuickGO ontologyBLASTP