Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:2175871 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21758712176206336hypothetical proteinBLASTP
21764452176714270hypothetical proteinBLASTP
217745921799992541penicillin-binding protein 1AQuickGO ontologyBLASTP
218061421817591146major facilitator family transporterQuickGO ontologyBLASTP
21817752182065291hypothetical proteinBLASTP
218246821835861119citrate synthaseQuickGO ontologyBLASTP
2183685218512114372-methylcitrate dehydrataseQuickGO ontologyBLASTP
21851402186048909carboxyvinyl-carboxyphosphonate phosphorylmutaseQuickGO ontologyBLASTP
218620321879121710acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
218792921888198912-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
218885621903161461methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
21903872191019633homoserinethreonine efflux protein putativeQuickGO ontologyBLASTP
219120321922581056enoyl-CoA hydrataseQuickGO ontologyBLASTP
21925752192832258hypothetical proteinBLASTP
21930162193255240hypothetical proteinBLASTP
219327121944281158exonuclease SbcD putativeQuickGO ontologyBLASTP
219442521975143090exonuclease putativeQuickGO ontologyBLASTP
21978832198083201hypothetical proteinBLASTP