Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:1523014 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1523014153806715054conserved repeat domain proteinQuickGO ontologyBLASTP
15381901539050861acetyltransferase GNAT familyQuickGO ontologyBLASTP
15390911539651561isochorismatase family proteinQuickGO ontologyBLASTP
15398331540093261hypothetical proteinBLASTP
15400961541007912transporter EamA familyQuickGO ontologyBLASTP
15410151541401387ribonuclease HQuickGO ontologyBLASTP
15414711542343873lacX protein putativeQuickGO ontologyBLASTP
15425271543012486hypothetical proteinBLASTP
15431561543815660hypothetical proteinBLASTP
15440381544286249hypothetical proteinBLASTP
15444061544603198cold shock protein CspBQuickGO ontologyBLASTP
15448661545594729hypothetical proteinBLASTP
15457341546366633hypothetical proteinBLASTP
15463861546679294hypothetical proteinBLASTP
15467591547388630fatty acid hydroxylase-like proteinQuickGO ontologyBLASTP
15476121547953342hypothetical proteinBLASTP
154795615495061551sodiumsolute symporter family proteinQuickGO ontologyBLASTP