Pre_GI Gene

Some Help

Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:1459357 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14593571460124768menaquinol-cytochrome c reductase cytochrome bc subunitQuickGO ontologyBLASTP
14602531460846594hypothetical proteinBLASTP
14608721461558687hypothetical proteinBLASTP
14616661462454789hypothetical proteinBLASTP
14624321463247816hypothetical proteinBLASTP
14633491463990642uracil-DNA glycosylase family proteinQuickGO ontologyBLASTP
14640191464900882hypothetical proteinBLASTP
14652261465624399hypothetical proteinBLASTP
14656241466424801dihydrodipicolinate reductaseQuickGO ontologyBLASTP
14664391466834396methylglyoxal synthaseQuickGO ontologyBLASTP
14668461467550705hypothetical proteinBLASTP
146754714686921146glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
146867914698721194polyA polymeraseQuickGO ontologyBLASTP
14698571470837981birA bifunctional proteinQuickGO ontologyBLASTP
14709381471333396hypothetical proteinBLASTP
147173414725738403-methyl-2-oxobutanoate hydroxymethyltransferaseQuickGO ontologyBLASTP
14725701473418849pantoate--beta-alanine ligaseQuickGO ontologyBLASTP
14734311473814384aspartate 1-decarboxylase precursorQuickGO ontologyBLASTP
147394314767472805ATP-dependent DNA helicaseQuickGO ontologyBLASTP
14771761477679504hypothetical proteinBLASTP
147769814788851188aspartate aminotransferaseQuickGO ontologyBLASTP
14790071479714708DNA replication protein DnaDQuickGO ontologyBLASTP
14797301480377648endonuclease IIIQuickGO ontologyBLASTP
14803811480899519hypothetical proteinBLASTP
148092314836132691penicillin-binding proteinQuickGO ontologyBLASTP