Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:1334000 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
133514513364881344potassium uptake protein TrkH familyQuickGO ontologyBLASTP
13365221336893372hypothetical proteinBLASTP
13371201337587468hypothetical proteinBLASTP
13381381338386249hypothetical proteinBLASTP
13385041338743240hypothetical proteinBLASTP
13388031339039237hypothetical proteinBLASTP
13391591340055897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
134033513420711737acetolactate synthase large subunitQuickGO ontologyBLASTP
13420681342577510acetolactate synthase III small subunitQuickGO ontologyBLASTP
134260413436141011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
1343616134513615212-isopropylmalate synthaseQuickGO ontologyBLASTP
1345214134627810653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
134627813476721395isopropylmalate isomerase large subunitQuickGO ontologyBLASTP
13476501348231582isopropylmalate isomerase small subunitQuickGO ontologyBLASTP
134854213498041263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
13497801350415636ATP phosphoribosyltransferaseQuickGO ontologyBLASTP
135042713517161290histidinol dehydrogenaseQuickGO ontologyBLASTP
13517161352300585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
13523011352930630imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
135290313536227201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneamino imidazole-4-carboxamide isomeraseQuickGO ontologyBLASTP
13536161354374759imidazole glycerol phosphate synthase subunit HisFQuickGO ontologyBLASTP
13543711354676306phosphoribosyl-AMP cyclohydrolaseQuickGO ontologyBLASTP
13546871355010324phosphoribosyl-ATP pyrophosphataseQuickGO ontologyBLASTP
135502213560381017histidinol-phosphataseQuickGO ontologyBLASTP