Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:1103729 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11037291104385657S-layer protein putativeQuickGO ontologyBLASTP
110456911061581590malate synthaseQuickGO ontologyBLASTP
110618211074591278isocitrate lyaseQuickGO ontologyBLASTP
11076331108421789trifolitoxin immunity domain proteinQuickGO ontologyBLASTP
11087731108976204cold shock protein CspAQuickGO ontologyBLASTP
11090031109353351hypothetical proteinBLASTP
11093791109564186hypothetical proteinBLASTP
11098461110427582competence transcription factor putativeQuickGO ontologyBLASTP
11107011111294594hypothetical proteinBLASTP
11113511111914564signal peptidase IQuickGO ontologyBLASTP
111203111155463516ATP-dependent nuclease subunit BQuickGO ontologyBLASTP
111554311192683726ATP-dependent nuclease subunit AQuickGO ontologyBLASTP
11192811119568288hypothetical proteinBLASTP
11196061119821216spore germination protein GerPFQuickGO ontologyBLASTP
11198641120250387spore germination protein GerPEQuickGO ontologyBLASTP
11202661120460195spore germination protein GerPDQuickGO ontologyBLASTP
11204671121081615spore germination protein GerPCQuickGO ontologyBLASTP
11211481121354207spore germination protein GerPBQuickGO ontologyBLASTP
11213691121590222spore germination protein GerPAQuickGO ontologyBLASTP
11221041123012909fumarylacetoacetate hydrolase family proteinQuickGO ontologyBLASTP
11230481123332285hypothetical proteinBLASTP
112343811246281191ornithine--oxo-acid transaminaseQuickGO ontologyBLASTP
11247791125144366hypothetical proteinBLASTP
11252031125757555hypothetical proteinBLASTP
112606511278431779asparagine synthetase glutamine-hydrolyzingQuickGO ontologyBLASTP