Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:872672 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8726728746481977DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
874704875036333hypothetical proteinBLASTP
875036875641606recombination protein RecRQuickGO ontologyBLASTP
875656875814159hypothetical proteinBLASTP
8758338777071875heat shock protein 90QuickGO ontologyBLASTP
877934878578645adenylate kinaseQuickGO ontologyBLASTP
878668879630963ferrochelataseQuickGO ontologyBLASTP
880228881217990CDP-6-deoxy-delta-34-glucoseen reductaseQuickGO ontologyBLASTP
881243882028786glucose-1-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
8819648831061143putative CDP-D-glucose-46-dehydrataseQuickGO ontologyBLASTP
8831248844371314putative CDP-4-keto-6-deoxy-D-glucose-3-dehydrataseQuickGO ontologyBLASTP
884534885331798paratose synthaseQuickGO ontologyBLASTP
8853328866151284hypothetical proteinBLASTP
8891358902771143putative mannosyltransferaseQuickGO ontologyBLASTP
8917088927571050putative mannosyltransferaseQuickGO ontologyBLASTP
893901894866966putative nucleotide di-P-sugar epimerase or dehydrataseQuickGO ontologyBLASTP
896468897211744glycosyltransferaseQuickGO ontologyBLASTP
8972168985891374phosphomannomutaseQuickGO ontologyBLASTP
8986378997881152ferric enterobactin transport protein FepEQuickGO ontologyBLASTP
8999929012961305inosine-guanosine kinaseQuickGO ontologyBLASTP
9013939030841692putative cationproton antiport proteinQuickGO ontologyBLASTP
9033199045331215putative membrane efflux proteinQuickGO ontologyBLASTP
906574906858285hypothetical proteinBLASTP
907150907638489hypothetical proteinBLASTP
907893908702810hypothetical proteinBLASTP
9092239121082886copper exporting ATPaseQuickGO ontologyBLASTP