Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:754340 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
7531667544071242Na-translocating NADH-quinone reductase subunit BQuickGO ontologyBLASTP
754340755197858Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
755190755819630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
755820756422603Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
7564387576611224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
7576427587241083thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
758737758964228hypothetical proteinBLASTP
759208760155948hypothetical proteinBLASTP
7605117615691059DNA polymerase IVQuickGO ontologyBLASTP
7616837631431461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
764141764296156hypothetical proteinBLASTP
765018765929912LysR family transcriptional regulatorQuickGO ontologyBLASTP
7663897679931605putative carbohydrate-binding proteinQuickGO ontologyBLASTP
768190768495306hypothetical proteinBLASTP
768922769380459xanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
7695077707541248fermentationrespiration switch proteinQuickGO ontologyBLASTP
770814771215402DNA-binding transcriptional regulator CrlQuickGO ontologyBLASTP
7713927724951104gamma-glutamyl kinaseQuickGO ontologyBLASTP
7725057737641260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
773863774024162hypothetical protein
774092774850759hypothetical proteinBLASTP
775033775302270hypothetical proteinBLASTP
775280775483204hypothetical proteinBLASTP
775548776069522hypothetical proteinBLASTP
776316776531216hypothetical protein
776769777356588putative methyltransferaseQuickGO ontologyBLASTP
777603778127525shikimate kinase IIQuickGO ontologyBLASTP
778383778553171hypothetical protein