Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:515744 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
515744516292549single-strand DNA-binding proteinQuickGO ontologyBLASTP
516539516856318hypothetical proteinBLASTP
5168675180151149alcohol dehydrogenaseQuickGO ontologyBLASTP
518082518906825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
5189195201811263L-rhamnose isomeraseQuickGO ontologyBLASTP
5201725216291458rhamnulokinaseQuickGO ontologyBLASTP
521628521834207phosphoribosylaminoimidazol AIR synthetaseQuickGO ontologyBLASTP
522056522877822transcriptional activator RhaSQuickGO ontologyBLASTP
523010523882873transcriptional activator RhaRQuickGO ontologyBLASTP
5240515251391089rhamnose-proton symporterQuickGO ontologyBLASTP
525239525505267hypothetical proteinBLASTP
525941526366426hypothetical proteinBLASTP
526596526763168hypothetical proteinBLASTP
5267785293482571enhancing factorQuickGO ontologyBLASTP
52978252985776tRNA-PheQuickGO ontologyBLASTP
530002530577576putative transcriptional regulatorQuickGO ontologyBLASTP
530609530794186hypothetical protein
5309975330122016putative oxidoreductase Fe-S binding subunitQuickGO ontologyBLASTP
5330355335925584Fe-4S ferrodoxinQuickGO ontologyBLASTP
5336155357622148formate dehydrogenase HQuickGO ontologyBLASTP
5358245376111788thioldisulfide interchange protein precursorQuickGO ontologyBLASTP
537587537946360divalent-cation tolerance protein CutAQuickGO ontologyBLASTP