Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4469156 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
446802944691591131putative oxidoreductaseQuickGO ontologyBLASTP
44691564470055900hypothetical proteinBLASTP
447045744716651209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
44717254472519795hypothetical proteinBLASTP
447252844770694542hypothetical proteinBLASTP
44771084477530423hypothetical proteinBLASTP
447753344797312199putative Rhs accessory genetic elementQuickGO ontologyBLASTP
44797534479929177hypothetical proteinBLASTP
44800114480499489putative transcriptional regulatory proteinQuickGO ontologyBLASTP
44805814480805225hypothetical proteinBLASTP
44808814481072192hypothetical proteinBLASTP
44811224481607486hypothetical proteinBLASTP
448160944829791371Rhs family proteinQuickGO ontologyBLASTP
448300744858982892hypothetical proteinBLASTP
44858644486322459hypothetical proteinBLASTP
448632844887302403putative Rhs accessory genetic elementQuickGO ontologyBLASTP