Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4381182 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
438291743848721956p-hydroxybenzoic acid efflux subunit AaeBQuickGO ontologyBLASTP
43848744385809936p-hydroxybenzoic acid efflux subunit AaeAQuickGO ontologyBLASTP
43858174386020204hypothetical proteinBLASTP
43862774386489213hypothetical protein
43865364387234699putative DNA-binding transcriptional regulatorQuickGO ontologyBLASTP
43874864388361876LysR family transcriptional regulatorQuickGO ontologyBLASTP
43885224388683162hypothetical proteinBLASTP
438877443911042331putative insecticial toxinQuickGO ontologyBLASTP
439114543947383594putative toxin subunitQuickGO ontologyBLASTP
439479543992854491insecticidal toxin complexQuickGO ontologyBLASTP
43994194399721303putative phage-related proteinQuickGO ontologyBLASTP
43997254400135411putative phage-related proteinQuickGO ontologyBLASTP
44001234400491369hypothetical proteinBLASTP
44004784400651174hypothetical proteinBLASTP
440069244035232832putative toxin subunitQuickGO ontologyBLASTP