Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4306716 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43067164307252537hypothetical proteinBLASTP
430795843091541197hypothetical proteinBLASTP
430916543102111047M48 peptidase family proteinQuickGO ontologyBLASTP
431035743115111155hypothetical proteinBLASTP
431150843128961389hypothetical proteinBLASTP
43129614313158198hypothetical proteinBLASTP
43133604313647288hypothetical proteinBLASTP
431399143153641374hypothetical proteinBLASTP
43153364316058723hypothetical proteinBLASTP
431610843174391332modification methylaseQuickGO ontologyBLASTP
43174524317919468UDP-glucose pyrophosphorylaseQuickGO ontologyBLASTP
43181664318396231hypothetical proteinBLASTP
431846343197791317hypothetical proteinBLASTP
431977643218392064hypothetical proteinBLASTP
432197343229951023transposase for insertion sequence IS100QuickGO ontologyBLASTP
43229924323774783transposaseIS proteinQuickGO ontologyBLASTP
43248564325749894LysR family transcriptional regulatorQuickGO ontologyBLASTP
43260114326715705hypothetical proteinBLASTP
43272564327624369hypothetical proteinBLASTP
43276524328551900putative tetrapyrrole methylaseQuickGO ontologyBLASTP
432851843305872070hypothetical proteinBLASTP