Pre_GI Gene

Some Help

Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4224500 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
422453942256781140chaperone protein DnaJQuickGO ontologyBLASTP
422579042277001911chaperone protein DnaKQuickGO ontologyBLASTP
42280744228664591hypothetical proteinBLASTP
422897342314202448hypothetical proteinBLASTP
423149042328781389putative transport proteinQuickGO ontologyBLASTP
42330064233593588molybdenum cofactor biosynthesis proteinQuickGO ontologyBLASTP
42336794233837159hypothetical proteinBLASTP
42338814234834954transaldolase BQuickGO ontologyBLASTP
42349014235083183hypothetical proteinBLASTP
42353634236142780hypothetical proteinBLASTP
423695942382481290threonine synthaseQuickGO ontologyBLASTP
42382524239181930homoserine kinaseQuickGO ontologyBLASTP
423918442416372454bifunctional aspartokinase Ihomeserine dehydrogenase IQuickGO ontologyBLASTP
42424754242648174hypothetical proteinBLASTP