Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4183297 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
418329741859002604putative Clp ATPaseQuickGO ontologyBLASTP
418590341869251023hypothetical proteinBLASTP
418687941887231845hypothetical proteinBLASTP
41887564189199444hypothetical proteinBLASTP
41892734189791519hypothetical proteinBLASTP
418995441914651512hypothetical proteinBLASTP
41914654192025561hypothetical proteinBLASTP
419203641930491014hypothetical proteinBLASTP
41933794194122744hypothetical proteinBLASTP
41953454195965621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
41962634197096834DNA-J like membrane chaperone proteinQuickGO ontologyBLASTP
419728141996232343organic solvent tolerance proteinQuickGO ontologyBLASTP
419969142009951305peptidyl-prolyl cis-trans isomerase SurAQuickGO ontologyBLASTP
4200967420197410084-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
42019674202785819dimethyladenosine transferaseQuickGO ontologyBLASTP
42027994203176378ApaGQuickGO ontologyBLASTP
42031934204062870diadenosine tetraphosphataseQuickGO ontologyBLASTP