Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:4045303 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
404530340466101308putative maltodextrin transport permeaseQuickGO ontologyBLASTP
404677040480321263putative sugar-binding proteinQuickGO ontologyBLASTP
404836840494741107sugar transport ATP-binding proteinQuickGO ontologyBLASTP
404993440515411608sugar transport ATP-binding proteinQuickGO ontologyBLASTP
405160740526171011sugar transport system permeaseQuickGO ontologyBLASTP
405301540540371023sugar-binding periplasmic proteinQuickGO ontologyBLASTP
40548164055334519hypothetical proteinBLASTP
40557104056567858hypothetical proteinBLASTP
40565294056684156hypothetical protein
40569914057671681hypothetical proteinBLASTP
40576714057991321hypothetical proteinBLASTP
40580904058395306hypothetical proteinBLASTP
40586124059391780hypothetical proteinBLASTP
40594534059668216hypothetical protein
406071740630412325hypothetical proteinBLASTP
40632864063570285putative colicin immunity proteinQuickGO ontologyBLASTP
40636174063874258hypothetical proteinBLASTP
40641934064387195hypothetical proteinBLASTP
406438440659221539hypothetical proteinBLASTP
406642640675681143hypothetical proteinBLASTP
40678974068202306hypothetical protein