Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3964468 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
396233139644752145putative hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
39644683965439972hypothetical proteinBLASTP
396586839669441077murein transglycosylase CQuickGO ontologyBLASTP
39671273967399273hypothetical proteinBLASTP
396757739688241248adenine DNA glycosylaseQuickGO ontologyBLASTP
39690303969749720tRNA guanine-N7-methyltransferaseQuickGO ontologyBLASTP
39697493970075327hypothetical proteinBLASTP
39701863971112927glutaminaseQuickGO ontologyBLASTP
397245339817859333putative virulence determinantQuickGO ontologyBLASTP
398190039831081209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
398329839844401143coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
39844213985014594putative deoxyribonucleotide triphosphate pyrophosphataseQuickGO ontologyBLASTP
39851143985404291hypothetical proteinBLASTP
39854013985955555hypothetical proteinBLASTP
39862433987064822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
39871973987925729hypothetical proteinBLASTP
398790939890391131pili biogenesis protein PilT-like ATPaseQuickGO ontologyBLASTP
398914839902631116agmatine deiminaseQuickGO ontologyBLASTP