Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3917254 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
391592939172571329putative siderophore biosynthesis protein IucDQuickGO ontologyBLASTP
391725439190021749putative siderophore biosynthesis protein IucCQuickGO ontologyBLASTP
39189993919949951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
392184439230671224hypothetical proteinBLASTP
39233573924190834hypothetical proteinBLASTP
392456739259431377hypothetical proteinBLASTP
39265113927254744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
39272353927885651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
39290553929705651hypothetical proteinBLASTP
39301563930551396putative lipoproteinQuickGO ontologyBLASTP
39306133930882270insertion element proteinQuickGO ontologyBLASTP
39310563931427372hypothetical proteinBLASTP
39328243933327504hypothetical proteinBLASTP
393337039349201551hypothetical proteinBLASTP
393493239362841353hypothetical proteinBLASTP
39362813936967687hypothetical proteinBLASTP
393696739387031737OmpA family membrane proteinQuickGO ontologyBLASTP
39387073939198492hemolysin-coregulated protein uncharacterizedQuickGO ontologyBLASTP
393961639422642649Clp ATPaseQuickGO ontologyBLASTP
394226139446092349hypothetical proteinBLASTP
394462439468462223hypothetical proteinBLASTP
39468473947347501hypothetical proteinBLASTP
39475313947725195hypothetical proteinBLASTP
39477513948029279insertion sequence proteinQuickGO ontologyBLASTP
39489503949585636ABC-type multidrugproteinlipid transport system ATPase componentQuickGO ontologyBLASTP
394960139518982298putative kinaseQuickGO ontologyBLASTP
39518853952652768hypothetical proteinBLASTP