Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3493607 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34927073493624918DNA-binding transcriptional regulator OxyRQuickGO ontologyBLASTP
349360734950071401soluble pyridine nucleotide transhydrogenaseQuickGO ontologyBLASTP
34952133495860648DNA-binding transcriptional repressor FabRQuickGO ontologyBLASTP
34958733496280408hypothetical proteinBLASTP
349641434975171104tRNA uracil-5--methyltransferaseQuickGO ontologyBLASTP
349791334998741962vitamin B12cobalamin outer membrane transporterQuickGO ontologyBLASTP
34998193500682864glutamate racemaseQuickGO ontologyBLASTP
3506403350647977tRNA-AspQuickGO ontologyBLASTP
3506488350656376tRNA-TrpQuickGO ontologyBLASTP
35075463508502957putative periplasmic protein precursorQuickGO ontologyBLASTP
350858835100781491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
351009035111091020putative sugar transport system permeaseQuickGO ontologyBLASTP
35111093512101993inner membrane ABC transporter permease protein YjfFQuickGO ontologyBLASTP
35120883512969882transcriptional regulator HdfRQuickGO ontologyBLASTP
35130043513426423hypothetical proteinBLASTP
351368335152061524putative magnesium chelatase family proteinQuickGO ontologyBLASTP
351582935174751647acetolactate synthase 2 catalytic subunitQuickGO ontologyBLASTP
35174723517729258acetolactate synthase 2 regulatory subunitQuickGO ontologyBLASTP