Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3333000 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
33331113334004894AraC family transcription regulatorQuickGO ontologyBLASTP
33340963334758663DedA family membrane proteinQuickGO ontologyBLASTP
333495133361621212cystathionine beta-lyaseQuickGO ontologyBLASTP
333661733376781062TonB complex proteinQuickGO ontologyBLASTP
33376823338113432biopolymer transport protein ExbDQuickGO ontologyBLASTP
333821033397661557hypothetical proteinBLASTP
33397913340363573hypothetical proteinBLASTP
33403473340820474hypothetical proteinBLASTP
33408173341587771TPR repeat-containing proteinQuickGO ontologyBLASTP
33415713342404834hypothetical proteinBLASTP
33424013343276876hypothetical proteinBLASTP
334327333445591287putative type II secretion proteinQuickGO ontologyBLASTP
334457133458031233hypothetical proteinBLASTP
33473113348177867hypothetical proteinBLASTP
33482293348651423hypothetical proteinBLASTP
33488003349309510transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
33521573352876720fimbrial chaperone proteinQuickGO ontologyBLASTP
335290133540071107fimbrial proteinQuickGO ontologyBLASTP
335421933552981080iron-enterobactin transporter periplasmic binding proteinQuickGO ontologyBLASTP
33561543357149996hypothetical proteinBLASTP
33572413357819579hypothetical proteinBLASTP
336007933612121134flagellar biosynthesis protein FlhBQuickGO ontologyBLASTP
33612123361985774flagellar biosynthetic protein FliRQuickGO ontologyBLASTP