Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3272765 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
327276532745851821hypothetical proteinBLASTP
327465032756991050multidrug resistance protein MdtNQuickGO ontologyBLASTP
32757093276044336hypothetical proteinBLASTP
32760413276241201hypothetical proteinBLASTP
327700732782391233putative aminotransferaseQuickGO ontologyBLASTP
327823232796831452hypothetical proteinBLASTP
32796873280133447hypothetical proteinBLASTP
32802673280890624hypothetical proteinBLASTP
32809063281286381putative translational inhibitor proteinQuickGO ontologyBLASTP
32815713281975405putative translational inhibitor proteinQuickGO ontologyBLASTP
32821903282492303hypothetical proteinBLASTP
32827523283354603hypothetical proteinBLASTP
32836303284562933LysR family regulatory proteinQuickGO ontologyBLASTP
32858783286078201hypothetical proteinBLASTP
32862123286466255hypothetical proteinBLASTP
328659932879811383hypothetical proteinBLASTP
32879483288460513hypothetical proteinBLASTP
32884813288942462hypothetical proteinBLASTP
328915532903631209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
32905503290888339hypothetical proteinBLASTP