Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:3021913 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
302191330233071395putative proteaseQuickGO ontologyBLASTP
30239433024833891lipid kinaseQuickGO ontologyBLASTP
30251203025629510hypothetical proteinBLASTP
30258603026747888hypothetical proteinBLASTP
30268093027609801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
30281193028598480hypothetical proteinBLASTP
302894730301551209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
30303403030861522hypothetical proteinBLASTP
30309603031253294hypothetical proteinBLASTP
30316563032051396hypothetical proteinBLASTP
30320893032508420hypothetical proteinBLASTP
30325723032970399hypothetical proteinBLASTP
30329943033473480hemolysin-coregulated protein uncharacterizedQuickGO ontologyBLASTP
30336333034142510transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
303446630360431578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP
303622330377701548inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
303785630392351380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
30393443039568225hypothetical proteinBLASTP
30396173040573957hypothetical proteinBLASTP
304092030424071488GTP-binding protein EngAQuickGO ontologyBLASTP
304255530437361182outer membrane protein assembly complex subunit YfgLQuickGO ontologyBLASTP
30437483044383636hypothetical proteinBLASTP
304439730456711275histidyl-tRNA synthetaseQuickGO ontologyBLASTP