Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2739878 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
273987827415961719urease subunit alphaQuickGO ontologyBLASTP
27418832742587705urease accessory protein UreEQuickGO ontologyBLASTP
27426092743295687urease accessory proteinQuickGO ontologyBLASTP
27434222744084663urease accessory proteinQuickGO ontologyBLASTP
27452392746231993putative urea transporterQuickGO ontologyBLASTP
274635627474381083putative nickel transport proteinQuickGO ontologyBLASTP
27476072747936330acid-resistance proteinQuickGO ontologyBLASTP
274854927497241176voltage-gated potassium channelQuickGO ontologyBLASTP
27498222750226405camphor resistance protein CrcBQuickGO ontologyBLASTP
27502422750622381camphor resistance protein CrcBQuickGO ontologyBLASTP
27507112750890180hypothetical proteinBLASTP
27516332751980348NN-diacetylchitobiose-specific PTS system transporter subunit IIBQuickGO ontologyBLASTP
275199127533521362NN-diacetylchitobiose-specific PTS system transporter subunit IICQuickGO ontologyBLASTP
27535192753866348NN-diacetylchitobiose-specific PTS system transporter subunit IIAQuickGO ontologyBLASTP
27539032754745843DNA-binding transcriptional regulator ChbRQuickGO ontologyBLASTP
27547972755558762hypothetical proteinBLASTP
27555652755741177hypothetical proteinBLASTP
27558532756221369hypothetical proteinBLASTP
27567162757243528replication initiation regulator SeqAQuickGO ontologyBLASTP
275727427589591686phosphoglucomutaseQuickGO ontologyBLASTP
27593332759575243hypothetical proteinBLASTP
27597032760131429hypothetical proteinBLASTP
27602262760855630DNA-binding transcriptional activator KdpEQuickGO ontologyBLASTP
276114827638742727sensor protein KdpDQuickGO ontologyBLASTP