Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2613456 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
261345626147391284putative lipoproteinQuickGO ontologyBLASTP
26153932616262870gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
26163112616847537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
26169252617392468hypothetical proteinBLASTP
261773026189651236hypothetical proteinBLASTP
261915626206191464NADH dehydrogenase subunit NQuickGO ontologyBLASTP
262062626221581533NADH dehydrogenase subunit MQuickGO ontologyBLASTP
262219826240331836NADH dehydrogenase subunit LQuickGO ontologyBLASTP
26240392624341303NADH dehydrogenase subunit KQuickGO ontologyBLASTP
26243382624883546NADH dehydrogenase subunit JQuickGO ontologyBLASTP
26248962625438543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
26254532626430978NADH dehydrogenase subunit HQuickGO ontologyBLASTP
262642726291712745NADH dehydrogenase subunit GQuickGO ontologyBLASTP
262925826306431386NADH dehydrogenase I subunit FQuickGO ontologyBLASTP
26306402631203564NADH dehydrogenase subunit EQuickGO ontologyBLASTP
263120626330021797bifunctional NADHubiquinone oxidoreductase subunit CDQuickGO ontologyBLASTP
26331432633820678NADH dehydrogenase subunit BQuickGO ontologyBLASTP
26339222634422501NADH dehydrogenase subunit AQuickGO ontologyBLASTP
26351002636044945LysR family transcriptional regulatorQuickGO ontologyBLASTP