Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2549680 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
254968025507201041LacI family transcriptional regulatorQuickGO ontologyBLASTP
255069225521251434phosphomannomutaseQuickGO ontologyBLASTP
255218325533041122putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
25535692554114546hypothetical proteinBLASTP
25543722554764393hypothetical proteinBLASTP
25549242555328405hypothetical proteinBLASTP
25554702555637168hypothetical proteinBLASTP
25558402556037198hypothetical proteinBLASTP
255604725637717725putative hemolysinQuickGO ontologyBLASTP
256392725656151689putative hemolysin activator proteinQuickGO ontologyBLASTP
25662682567233966putative dioxygenase beta subunitQuickGO ontologyBLASTP
256732925685371209putative dioxygenase alpha subunitQuickGO ontologyBLASTP
256857025700511482putative transporterQuickGO ontologyBLASTP
25705822570764183hypothetical proteinBLASTP
257083325719301098tartrate dehydrogenaseQuickGO ontologyBLASTP
25720212572962942LysR family transcriptional regulatorQuickGO ontologyBLASTP
257320925742131005LacI family transcriptional regulatoryproteinQuickGO ontologyBLASTP
25743462575338993putative sugar transport system permease proteinQuickGO ontologyBLASTP
257533525768251491putative sugar transport system ATP-binding proteinQuickGO ontologyBLASTP
25768652577782918sugar binding protein precursorQuickGO ontologyBLASTP
257795725791801224putative zinc-binding dehydrogenaseQuickGO ontologyBLASTP
25797662580434669hypothetical proteinBLASTP
25806302581172543hypothetical proteinBLASTP
25814102582348939hypothetical proteinBLASTP
25826642583194531outer membrane protein XQuickGO ontologyBLASTP
25835932584480888threonine and homoserine efflux systemQuickGO ontologyBLASTP
25844962584993498hypothetical proteinBLASTP
25850162585792777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
25860492586552504DNA starvationstationary phase protection protein DpsQuickGO ontologyBLASTP
258687225879991128hypothetical proteinBLASTP