Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2508671 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
250867125123363666ribonuclease EQuickGO ontologyBLASTP
25125402512971432hypothetical proteinBLASTP
251311625141621047dihydroorotaseQuickGO ontologyBLASTP
25144752514720246DNA damage-inducible protein IQuickGO ontologyBLASTP
251548525166931209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
251705425181691116N-methyltryptophan oxidaseQuickGO ontologyBLASTP
25184092519050642LuxR family regulatory proteinQuickGO ontologyBLASTP
251962225206801059putative transport proteinQuickGO ontologyBLASTP
252082925219501122hypothetical proteinBLASTP
25222552522659405hypothetical proteinBLASTP
25227492522910162hypothetical proteinBLASTP
25229472523645699hypothetical proteinBLASTP
25240432524699657N-acylhomoserine lactone synthase YpeIQuickGO ontologyBLASTP
25246922525429738quorum-sensing transcriptional activator YpeRQuickGO ontologyBLASTP
25259162526896981LysR family transcriptional regulatorQuickGO ontologyBLASTP
252729025286481359putative transporter proteinQuickGO ontologyBLASTP
25286952529198504hypothetical proteinBLASTP
252920925302281020putative oxidoreductaseQuickGO ontologyBLASTP
25303062530860555hypothetical proteinBLASTP
253087125318751005hypothetical proteinBLASTP
25318932532843951hypothetical proteinBLASTP
253284025341861347hypothetical proteinBLASTP