Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2180303 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
218030321821531851protease 4QuickGO ontologyBLASTP
21823162182867552hypothetical proteinBLASTP
218309221841381047selenophosphate synthetaseQuickGO ontologyBLASTP
218421221861401929DNA topoisomerase IIIQuickGO ontologyBLASTP
21861372186427291hypothetical proteinBLASTP
21864402186826387pyrimidine deoxynucleoside triphosphate pyrophosphohydrolaseQuickGO ontologyBLASTP
21869242187730807exonuclease IIIQuickGO ontologyBLASTP
21885402189400861LysR family transcriptional regulatorQuickGO ontologyBLASTP
2189908218999285tRNA-TyrQuickGO ontologyBLASTP
21901412190989849formyltetrahydrofolate deformylaseQuickGO ontologyBLASTP
21910732191537465hypothetical proteinBLASTP
219287121938871017response regulator of RpoSQuickGO ontologyBLASTP
219416721955401374putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP
21959752196382408global DNA-binding transcriptional dual regulator H-NSQuickGO ontologyBLASTP
21971322197722591thymidine kinaseQuickGO ontologyBLASTP
219847322011482676bifunctional acetaldehyde-CoAalcohol dehydrogenaseQuickGO ontologyBLASTP
22013622201571210hypothetical proteinBLASTP
22019552202599645hypothetical proteinBLASTP
220343722050741638periplasmic oligopeptide-binding protein precursorQuickGO ontologyBLASTP
22051612206081921oligopeptide transporter permeaseQuickGO ontologyBLASTP
22061002207005906oligopeptide transport system permease proteinQuickGO ontologyBLASTP
220701722080181002oligopeptide transporter ATP-binding componentQuickGO ontologyBLASTP
220801522090161002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP