Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:2043730 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
204373020458922163hypothetical proteinBLASTP
204647120485822112hypothetical proteinBLASTP
20488292049467639hypothetical proteinBLASTP
20496022050261660hypothetical proteinBLASTP
20503662051046681putative dehydrogenaseQuickGO ontologyBLASTP
20513872052337951hypothetical proteinBLASTP
20523242053256933hypothetical proteinBLASTP
20532622054167906hypothetical proteinBLASTP
205495820560311074hypothetical proteinBLASTP
20562442056714471hypothetical proteinBLASTP
20567692057191423putative decarboxylaseQuickGO ontologyBLASTP
205746820588591392putative two-component system sensor proteinQuickGO ontologyBLASTP
20588652059557693transcriptional activatorQuickGO ontologyBLASTP
205982220609131092alphabeta fold family hydrolaseQuickGO ontologyBLASTP
20610622061769708flavodoxinQuickGO ontologyBLASTP
20617842062479696hypothetical proteinBLASTP
20626872063529843hypothetical proteinBLASTP