Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1794490 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17944901794699210DnaK suppressor proteinQuickGO ontologyBLASTP
17946891795270582hypothetical proteinBLASTP
17952761795440165hypothetical proteinBLASTP
17954591795740282putative transcriptional regulatorQuickGO ontologyBLASTP
17957841796338555hypothetical proteinBLASTP
17963461796768423hypothetical proteinBLASTP
179758417996052022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
179973618013131578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
18013171802120804yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
180211718032171101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
180321418127059492yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
181279318189186126yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
18190911820050960transcriptional regulator YbtAQuickGO ontologyBLASTP
182021718220191803permease and ATP-binding protein of yersiniabactin-iron ABC transporterQuickGO ontologyBLASTP
182200618238081803inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
182367818250811404putative signal transducerQuickGO ontologyBLASTP
182510918264131305salicylate synthase Irp9QuickGO ontologyBLASTP
182660718278691263integraseQuickGO ontologyBLASTP
1828031182810676tRNA-AsnQuickGO ontologyBLASTP
18284091829149741pili assembly chaperoneQuickGO ontologyBLASTP
182914618304951350hypothetical proteinBLASTP
183051118331022592fimbrial usher proteinQuickGO ontologyBLASTP
18331511833795645pili assembly chaperoneQuickGO ontologyBLASTP
18338881834418531fimbrial proteinQuickGO ontologyBLASTP