Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1663672 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16660601666350291hypothetical proteinBLASTP
16663311666603273hypothetical proteinBLASTP
16666341666993360hypothetical proteinBLASTP
16669901667289300hypothetical proteinBLASTP
16673061667593288hypothetical proteinBLASTP
16680281668243216hypothetical proteinBLASTP
16682401668545306hypothetical proteinBLASTP
16685501668804255hypothetical proteinBLASTP
16691931669639447hypothetical proteinBLASTP
16697111670670960transposaseQuickGO ontologyBLASTP
16708901671234345hemolysin-coregulated protein uncharacterizedQuickGO ontologyBLASTP
16712601671484225hypothetical protein
16718891672062174hypothetical proteinBLASTP
16723071672453147hypothetical proteinBLASTP
16730971673675579integraseQuickGO ontologyBLASTP
1673973167405886tRNA-LeuQuickGO ontologyBLASTP
1674069167414274tRNA-CysQuickGO ontologyBLASTP
1674195167427076tRNA-GlyQuickGO ontology
16744151674963549phosphatidylglycerophosphate synthetaseQuickGO ontologyBLASTP
167502216768751854excinuclease ABC subunit CQuickGO ontologyBLASTP
16768471677503657response regulatorQuickGO ontologyBLASTP
16781661678390225hypothetical proteinBLASTP
16785151678859345hypothetical proteinBLASTP
16788871679141255hypothetical proteinBLASTP
16792601679442183hypothetical proteinBLASTP
16794811680032552attachment invasion locus proteinQuickGO ontologyBLASTP
1680719168079476tRNA-LysQuickGO ontologyBLASTP
168114716825711425D-alanineD-serineglycine permeaseQuickGO ontologyBLASTP
168269716838751179hypothetical proteinBLASTP
16842541684868615TrpR binding protein WrbAQuickGO ontologyBLASTP
168495416862581305iron-dependent peroxidaseQuickGO ontologyBLASTP
168626916874231155hypothetical proteinBLASTP