Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1520000 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
152018215219451764ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
15221731522817645hypothetical proteinBLASTP
152283915240471209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
15242141525014801molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
152498615262601275molybdopterin biosynthesis protein MoeAQuickGO ontologyBLASTP
152679515281051311putative heme-binding proteinQuickGO ontologyBLASTP
15281151528783669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
152878515300471263hypothetical proteinBLASTP
153004915324092361hypothetical proteinBLASTP
15324931532705213hypothetical proteinBLASTP
15329621533804843putative esteraseQuickGO ontologyBLASTP
153382515349641140alcohol dehydrogenaseQuickGO ontologyBLASTP
15352381536107870LysR family transcriptional regulatorQuickGO ontologyBLASTP
153624315373941152hypothetical proteinBLASTP
15375241538240717GTP cyclohydrolase IQuickGO ontologyBLASTP
153829515394611167hypothetical proteinBLASTP
154009815412011104galactose-binding proteinQuickGO ontologyBLASTP
154143115429511521galactosemethyl galaxtoside transporter ATP-binding proteinQuickGO ontologyBLASTP
154297215439821011beta-methylgalactoside transporter inner membrane componentQuickGO ontologyBLASTP