Pre_GI Gene

Some Help

Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1467772 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
146922714702491023transposase for insertion sequence IS100QuickGO ontologyBLASTP
14702461471028783transposaseIS proteinQuickGO ontologyBLASTP
147197914744082430putative oxidoreductaseQuickGO ontologyBLASTP
14745501475296747putative short chain dehydrogenaseQuickGO ontologyBLASTP
14759251476245321hypothetical proteinBLASTP
14765091477033525putative myristoyl-acyl carrier dehydrataseQuickGO ontologyBLASTP
147702314783061284putative beta-ketoacyl-acyl-carrier-protein synthaseQuickGO ontologyBLASTP
14782541479045792putative beta-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
147906114802991239putative hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
14802411481011771putative enoyl-CoA hydrataseQuickGO ontologyBLASTP
14809891481765777polyketide biosynthesis enoyl-CoA hydrataseQuickGO ontologyBLASTP
14817681482556789putative short chain dehydrogenaseQuickGO ontologyBLASTP
14825951483083489hypothetical proteinBLASTP
14831211483369249putative acyl carrier proteinQuickGO ontologyBLASTP
14834681484316849putative acyl transferaseQuickGO ontologyBLASTP
14853021485805504hypothetical proteinBLASTP
148584814873921545hypothetical proteinBLASTP
148740414887561353hypothetical proteinBLASTP
14887531489439687hypothetical proteinBLASTP
148943914911751737hypothetical proteinBLASTP
14911791491670492hemolysin-coregulated protein uncharacterizedQuickGO ontologyBLASTP
149205814947002643putative ATPase subunit of ATP-dependent proteaseQuickGO ontologyBLASTP
149470314970512349hypothetical proteinBLASTP
149706714993672301hypothetical proteinBLASTP
14993641500137774hypothetical proteinBLASTP
15002911500551261ABC-type multidrugproteinlipid transport system ATPase componentQuickGO ontologyBLASTP
150056715027502184hypothetical proteinBLASTP
15029231503393471hypothetical proteinBLASTP
15041261504446321putative transposaseQuickGO ontologyBLASTP