Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1413305 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
141330514150051701fructose-specific PTS system IIBC componentQuickGO ontologyBLASTP
141502014159589391-phosphofructokinaseQuickGO ontologyBLASTP
141595514170881134bifunctional fructose-specific PTS IIAHPr proteinQuickGO ontologyBLASTP
14172691417805537ADP-ribose pyrophosphataseQuickGO ontologyBLASTP
14179181418916999putative ABC transport integral membrane subunitQuickGO ontologyBLASTP
141895214205261575putative ABC transport ATP-binding subunitQuickGO ontologyBLASTP
142063514217231089putative periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
14218631422615753putative ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
142259314241641572putative carbohydrate kinaseQuickGO ontologyBLASTP
142416814256641497putative aldehyde dehydrogenaseQuickGO ontologyBLASTP
142601514271571143hypothetical proteinBLASTP
14271541428119966putative D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
14281301428945816putative short chain oxidoreductaseQuickGO ontologyBLASTP
14289231429297375hypothetical proteinBLASTP
142962514308691245tryptophan-specific transport proteinQuickGO ontologyBLASTP
14309731431545573elongation factor PQuickGO ontologyBLASTP
143168514328781194mannonate dehydrataseQuickGO ontologyBLASTP
143344414349161473putative D-mannonate oxidoreductaseQuickGO ontologyBLASTP
14350451435806762putative transcriptional regulatory proteinQuickGO ontologyBLASTP
14359541436337384hypothetical proteinBLASTP
14365961437579984putative cobalamin synthesis proteinQuickGO ontologyBLASTP