Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1230976 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123097612333392364putative penicillin-binding proteinQuickGO ontologyBLASTP
12335521233854303putative regulatorQuickGO ontologyBLASTP
12342421234415174hypothetical protein
12344701235051582hypothetical proteinBLASTP
12351231235326204hypothetical proteinBLASTP
12352801235720441hypothetical proteinBLASTP
12357591235959201hypothetical proteinBLASTP
12359521236353402hypothetical proteinBLASTP
12363651236937573hypothetical proteinBLASTP
12369611237212252hypothetical proteinBLASTP
12372511237490240hypothetical proteinBLASTP
123829912402151917putaive autotransporter proteinQuickGO ontologyBLASTP
12407501241331582hypothetical proteinBLASTP
124173312429411209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
12431961243357162hypothetical proteinBLASTP
124339312456002208hypothetical proteinBLASTP
12455931246123531hypothetical proteinBLASTP
124628212486632382putative beta-glucosidaseQuickGO ontologyBLASTP
124874212503701629hypothetical proteinBLASTP