Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1130251 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113025111315311281type II citrate synthaseQuickGO ontologyBLASTP
11316391132217579heat shock protein GrpEQuickGO ontologyBLASTP
11323411133222882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
113320111349701770recombination and repair proteinQuickGO ontologyBLASTP
11350751135425351hypothetical proteinBLASTP
11355751135859285hypothetical proteinBLASTP
11358521136388537hypothetical proteinBLASTP
11364351136929495SsrA-binding proteinQuickGO ontologyBLASTP
11375131138022510transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
113821311394451233prophage CP4-57 integraseQuickGO ontologyBLASTP
113952411406121089hypothetical proteinBLASTP
114066311423331671hypothetical proteinBLASTP
11424951142722228hypothetical proteinBLASTP
11429531143126174hypothetical proteinBLASTP
11432181143508291hypothetical proteinBLASTP
11435211144417897putative DNA-binding prophage proteinQuickGO ontologyBLASTP
11444101144610201transcriptional regulatorQuickGO ontologyBLASTP
11446101145152543putative prophage proteinQuickGO ontologyBLASTP
11451151146104990hypothetical proteinBLASTP
114610111471891089putative regulatory prophage proteinQuickGO ontologyBLASTP
11472361147430195hypothetical proteinBLASTP
11475381147858321putative DNA-binding prophage proteinQuickGO ontologyBLASTP
11478581148178321hypothetical proteinBLASTP
114878011498021023transposase for insertion sequence IS100QuickGO ontologyBLASTP
11497991150581783transposaseIS proteinQuickGO ontologyBLASTP
11511281151391264IS1400 transposaseQuickGO ontologyBLASTP
11518221152073252hypothetical proteinBLASTP
11527841153551768hypothetical proteinBLASTP
11538831154170288LexA regulated proteinQuickGO ontologyBLASTP